Kevin Bacon (born July 8, 1958) - American actor known for his versatility in portraying various movie roles. He plays the guitar and is part of The Bacon Brothers along with his brother Michael.
Johnny Carson (1925 - 2005) - American comedian known for hosting The Tonight Show. He received 4 Emmys and the Presidential Medal of Freedom in 1992. Carson reportedly played the drums.
Charlie Chaplin (1889 - 1977) - British actor known for his comedic talent. One of his famous movie is The Gold Rush which he directed and released in 1925. He played the accordion.
Katie Couric (born on Jan. 7, 1957) - Hosted NBC's Today show before signing on to be the anchor and editor of CBS Evening News. She plays the piano.
Clint Eastwood (born May 31, 1930) - Hollywood actor who branched out to directing and producing films. Known for his Dirty Harry movies, he also directed a film titled Bird which is about the life of jazz saxophonist Charlie Parker. Eastwood plays the piano.
Jamie Foxx (born on Dec. 13, 1967) - Stand-up comedian who also proved to be a good dramatic actor in a movie titled Ray, a film about the life of musician Ray Charles in which Foxx played the lead role. He plays the piano.
Jennifer Garner (born April 17, 1972) - Hollywood actress known for her role in the TV series Alias as well as other film roles. Garner graduated from Charleston's George Washington High School where she played the saxophone.
Richard Gere (born August 31, 1949) - American actor known for his roles in such movies as Pretty Woman and An Officer and A Gentleman. Gere graduated from North Syracuse Central High School where he played the trumpet
Kelsey Grammer (born February 21, 1955) - Actor, writer, producer and director known for his role as Dr. Frasier Crane in the sitcoms Cheers and Frasier. Grammer actually attended the Julliard School for 2 years; he plays the piano.
Andy Griffith (born on June 1, 1926) - Best known for his role as Andy Taylor on The Andy Griffith Show. He has a B.A. in music from the University of North Carolina. Griffith plays the guitar.
Dustin Hoffman (born on August 8, 1937) - American actor known for such films as The Graduate, Kramer vs. Kramer and Tootsie. He plays the piano.
Bob Hope (1903 - 2003) - Entertainer, radio and TV personality, stage and film actor. He played the saxophone.
Anthony Hopkins (born December 31, 1937) - Stage and film actor known for his roles in movies such as The Silence of the Lambs, Hannibal and Nixon. He plays the piano.
Steve Martin (born August 14, 1945) - American comedian, actor, producer, director and writer. He is also a brilliant musician who plays the banjo and is an excellent bluegrass picker.
Alyssa Milano (born December 19, 1972) - American actress known hor her role in the sitcom Who's the Boss and her role as good witch Phoebe Halliwell in the TV series Charmed. She plays the piano and flute.
Julia Roberts (born October 28, 1967) - Considered one of the highest paid actress in Hollywood. She is known for her movies such as Steel Magnolias, Pretty Woman, My Best Friend's Wedding, Ocean's 11 and Ocean's 12. She plays the clarinet and oboe.
Harry Smith (born August 21, 1951) - TV and radio personality. Anchor of CBS' The Early Show, was also a contributor for CBS Evening News, sometimes anchors and is a correspondent for CBS News Sunday Morning. He plays the tuba.
John Stamos (born August 19, 1963) - Known for his portrayal of Jesse Katsopolis in the show Full House. He played drums when he was in high school.
Meryl Streep (born June 22, 1949) - The most Academy Award nominated actress, she is known through her roles in memorable films like Kramer vs. Kramer and Sophie's Choice. She plays the violin.
Bruce Willis (born March 19, 1955)- American actor known for the TV series Moonlighting and for his role on films such as the Die Hard movies. He plays the harmonica.
Paula Zahn (born February 24, 1956) - Newscaster and host of CNN's Paula Zahn Now. She plays the cello.